0001356576 2023-01-01 2023-12-31 0001356576 2022-01-01 2022-12-31 0001356576 2021-01-01 2021-12-31 0001356576 2020-01-01 2020-12-31 0001356576 supn:EquityAwardsValueInCompensationTableForTheApplicableYearMember ecd:PeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsMember ecd:PeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsValueInCompensationTableForTheApplicableYearMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsYearEndFairValueOfAwardsGrantedInCurrentYearMember ecd:PeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedAwardsGrantedInPriorYearsMember ecd:PeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfVestedAwardsDuringCurrentYearMember ecd:PeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearAwardsVestedDuringCurrentYearMember ecd:PeoMember 2023-01-01 2023-12-31 0001356576 supn:FairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearMember ecd:PeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsYearEndFairValueOfAwardsGrantedInCurrentYearMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedAwardsGrantedInPriorYearsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfVestedAwardsDuringCurrentYearMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001356576 supn:EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearAwardsVestedDuringCurrentYearMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001356576 supn:FairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001356576 1 2023-01-01 2023-12-31 0001356576 2 2023-01-01 2023-12-31 iso4217:USD pure SUPERNUS PHARMACEUTICALS, INC. <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;"> <span style="letter-spacing:-0.2pt;">PAY VERSUS PERFORMANCE</span><span style="font-weight:normal;letter-spacing:0.2pt;"> </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;"> <span style="letter-spacing:0.2pt;">In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer (“PEO”) and our NEOs other than </span> </div><div style="margin-top:6pt;margin-bottom:17.45pt;margin-left:69.66pt;width:456pt;"> <div style="width:456pt; line-height:12.5pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">our PEO (“Non-PEO NEOs”) and Company performance for the fiscal years listed below. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown. </span> </div> <table style="width:456pt;height:149.5pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;height:27.25pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td rowspan="2" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:50pt;text-align:left;"> <div style="white-space:nowrap; line-height:9pt; padding-bottom:0.333333333333333pt;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" rowspan="2" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center; line-height:9pt; padding-bottom:0.333333333333333pt;"> <span style="letter-spacing:-0.16pt;">Summary <br/> Compensation <br/> Table Total <br/> for Jack <br/> Khattar</span><span style=" position:relative; bottom:3.25pt;line-height:6pt;font-size:5pt;letter-spacing:-0.12pt;">(1)</span> <br/> <span style="letter-spacing:-0.16pt;">($) </span> </div> </td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" rowspan="2" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center; line-height:9pt; padding-bottom:0.333333333333333pt;"> <span style="letter-spacing:-0.16pt;">Compensation <br/> Actually <br/> Paid to <br/> Jack <br/> Khattar</span><span style=" position:relative; bottom:3.25pt;line-height:6pt;font-size:5pt;letter-spacing:-0.12pt;">(1)(2)(3)</span> <br/> <span style="letter-spacing:-0.16pt;">($) </span> </div> </td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" rowspan="2" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center; line-height:9pt; padding-bottom:0.333333333333333pt;"> <span style="letter-spacing:-0.16pt;">Average <br/> Summary <br/> Compensation <br/> Table Total <br/> for Non-PEO <br/> NEOs</span><span style=" position:relative; bottom:3.25pt;line-height:6pt;font-size:5pt;letter-spacing:-0.12pt;">(1)</span> <br/> <span style="letter-spacing:-0.16pt;">($) </span> </div> </td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" rowspan="2" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center; line-height:9pt; padding-bottom:0.333333333333333pt;"> <span style="letter-spacing:-0.16pt;">Average <br/> Compensation <br/> Actually <br/> Paid to <br/> Non-PEO <br/> NEOs</span><span style=" position:relative; bottom:3.25pt;line-height:6pt;font-size:5pt;letter-spacing:-0.12pt;">(1)(2)(3)</span> <br/> <span style="letter-spacing:-0.16pt;">($) </span> </div> </td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="10" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Value of Initial Fixed <br/> $100 Investment <br/> based on:</span><span style=" position:relative; bottom:3.25pt;line-height:5pt;font-size:5pt;letter-spacing:-0.12pt;">(4)</span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" rowspan="2" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center; line-height:9pt; padding-bottom:0.333333333333333pt;"> <span style="letter-spacing:-0.16pt;">Net <br/> Income <br/> ($ Millions) </span> </div> </td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" rowspan="2" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center; line-height:9pt; padding-bottom:0.333333333333333pt;"> <span style="letter-spacing:-0.16pt;">Gross <br/> Product <br/> Sales <br/> ($ Millions)</span><span style=" position:relative; bottom:3.25pt;line-height:5pt;font-size:5pt;letter-spacing:-0.12pt;">(5)</span> </div> </td> <td rowspan="2" style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:9pt;height:49.5pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:2.583pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Total <br/> Shareholder <br/> Return <br/> (“TSR”) <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:2.583pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Peer <br/> Group <br/> TSR <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:4pt;">​</td> </tr> <tr style="line-height:8pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="padding:3.25pt 0pt 2.5pt 0pt; width:50pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">(a) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(b) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(c) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(d) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(e) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(f) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(g) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(h) </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td colspan="4" style="padding:3.25pt 0pt 2.5pt 0pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">(i) </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 1.5pt 0pt; width:50pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">13,278,093</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">13,491,498</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,806,329</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,691,851</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">122.01</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">118.87</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">1.3</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">1,071</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:50pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2022 </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">10,012,717</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">11,056,323</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,167,214</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,433,071</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">150.38</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">113.65</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">60.7</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">1,181</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:50pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2021 </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">8,116,721</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">7,914,950</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">979,005</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">601,468</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">122.93</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">126.45</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">53.4</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">1,021</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:50pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2020 </span> </div> </td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">6,669,046</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">6,134,966</td> <td style="padding:0pt;padding-left:0.960000000000001pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,204,624</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">939,602</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">106.07</td> <td style="padding:0pt;padding-left:6.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">126.42</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">127.0</td> <td style="padding:0pt;padding-left:8.14pt;width:0pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt; width:4pt;">​</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:17.25pt; text-align:right; white-space:nowrap;">951</td> <td style="padding:0pt;padding-left:11.64pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> <div style="text-indent:20pt; margin-top:9.2pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">1.   Jack Khattar was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below. </span> </div> <table style="width:456pt;height:83.5pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:8pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt; width:145.47pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">2020 </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">2021 </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">2022-2023 </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">James P. Kelly </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Timothy C. Dec </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Timothy C. Dec </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:0.2pt;">Stefan K.F. Schwabe, M.D., Ph.D. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Jonathan Rubin, MD </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Jonathan Rubin, MD </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Padmanabh P. Bhatt, Ph.D. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:0.2pt;">Padmanabh P. Bhatt, Ph.D. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:0.2pt;">Padmanabh P. Bhatt, Ph.D. </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Gregory S. Patrick </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Tami Martin, R.N., Esq. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Frank Mottola </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Tami Martin, R.N., Esq. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">James P. Kelly </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">—</span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> <div style="text-indent:20pt; margin-top:9.2pt; width:456pt; line-height:12.5pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">2.   The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below. </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12.5pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">3.   Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. Amounts in the Inclusion of Equity Values column are set forth in the table further below. </span> </div> <table style="width:456pt;height:59.4999999999999pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:168.39pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Summary <br/> Compensation Table <br/> Total for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Exclusion of <br/> Stock Awards and <br/> Option Awards for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Inclusion of <br/> Equity Values for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Compensation <br/> Actually Paid <br/> to Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:168.39pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:11.265pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">13,278,093</td> <td style="padding:0pt;padding-left:11.265pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:6.29pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:36.75pt; text-align:right; white-space:nowrap;">(11,435,200<span style="position:absolute;">)</span></td> <td style="padding:0pt;padding-left:6.29pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:6.07pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">11,648,605</td> <td style="padding:0pt;padding-left:6.07pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:3.695pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">13,491,498</td> <td style="padding:0pt;padding-left:3.695pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> <table style="width:456pt;height:68.5pt;margin-top:13pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:156.3pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average Summary <br/> Compensation Table <br/> Total for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average Exclusion of <br/> Stock Awards and <br/> Option Awards for <br/> Non-PEO NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average Inclusion of <br/> Equity Values for <br/> Non-PEO NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Compensation <br/> Actually Paid <br/> to Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:156.3pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:13.765pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,806,329</td> <td style="padding:0pt;padding-left:13.765pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:12.835pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:33pt; text-align:right; white-space:nowrap;">(1,175,975<span style="position:absolute;">)</span></td> <td style="padding:0pt;padding-left:12.835pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:13.31pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,061,497</td> <td style="padding:0pt;padding-left:13.31pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,691,851</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> </div><div style="text-indent:20pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: </span> </div> <table style="width:456pt;height:131.5pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:100.38pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Year-End <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> That <br/> Remained <br/> Unvested as <br/> of Last Day of <br/> Year for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Last Day of <br/> Year of <br/> Unvested <br/> Equity <br/> Awards for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Vesting-Date <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> that Vested <br/> During Year <br/> for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Vesting <br/> Date of <br/> Unvested <br/> Equity <br/> Awards that <br/> Vested During <br/> Year for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Fair Value at <br/> Last Day of <br/> Prior Year of <br/> Equity Awards <br/> Forfeited <br/> During Year <br/> for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Total − <br/> Inclusion <br/> of <br/> Equity <br/> Values <br/> for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:100.38pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:4.245pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">6,566,381</td> <td style="padding:0pt;padding-left:4.245pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,956,489</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:1.5pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,012,900</td> <td style="padding:0pt;padding-left:1.5pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">2,112,835</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:19.25pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;"><span style="-sec-ix-hidden: hidden-fact-1">—</span></td> <td style="padding:0pt;padding-left:19.25pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">11,648,605</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> <table style="width:456pt;height:149.5pt;margin-top:13pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:98.49pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Year-End <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> That <br/> Remained <br/> Unvested as of <br/> Last Day of <br/> Year for <br/> Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Last Day of <br/> Year of <br/> Unvested <br/> Equity <br/> Awards for <br/> Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Vesting-Date <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> that Vested <br/> During Year <br/> for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Vesting <br/> Date of <br/> Unvested <br/> Equity <br/> Awards that <br/> Vested During <br/> Year for <br/> Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Fair <br/> Value at Last <br/> Day of Prior <br/> Year of Equity <br/> Awards <br/> Forfeited <br/> During Year <br/> for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Total − <br/> Average <br/> Inclusion <br/> of <br/> Equity <br/> Values <br/> for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:98.49pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:7.555pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">708,219</td> <td style="padding:0pt;padding-left:7.555pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:7.99pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">346,240</td> <td style="padding:0pt;padding-left:7.99pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:17.83pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;"><span style="-sec-ix-hidden: hidden-fact-2">—</span></td> <td style="padding:0pt;padding-left:17.83pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:10.49pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">21,753</td> <td style="padding:0pt;padding-left:10.49pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:8.975pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:23.25pt; text-align:right; white-space:nowrap;">(14,715<span style="position:absolute;">)</span></td> <td style="padding:0pt;padding-left:8.975pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:2.625pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,061,497</td> <td style="padding:0pt;padding-left:2.625pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">4.   The Peer Group TSR set forth in this table utilizes the Nasdaq Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2023. The comparison assumes $100 was invested for the period starting December 31, 2019, through the end of the listed year in the Company and in the Nasdaq Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance. Cumulative TSR is calculated by dividing (i) the sum of (a) the cumulative amount of any dividends for the measurement period and (b) the change in the company’s share price during the measurement period by (ii) the share price at the beginning of the measurement period. This assumes dividend reinvestment. </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">5.   We determined Gross Product Sales to be the most important financial performance measure used to link Company performance to Compensation Actually Paid to our PEO and Non-PEO NEOs in 2023 and 2022. This performance measure may not have been the most important financial performance measure for years prior and we may determine a different financial performance measure to be the most important financial performance measure in future years. </span> </div> Gross Product Sales 13278093 13491498 1806329 1691851 122.01 118.87 1300000 1071000000 10012717 11056323 1167214 1433071 150.38 113.65 60700000 1181000000 8116721 7914950 979005 601468 122.93 126.45 53400000 1021000000 6669046 6134966 1204624 939602 106.07 126.42 127000000 951000000 <div style="text-indent:20pt; margin-top:9.2pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">1.   Jack Khattar was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below. </span> </div><table style="width:456pt;height:83.5pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:8pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt; width:145.47pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">2020 </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">2021 </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:19.59pt;">​</td> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:-0.16pt;">2022-2023 </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">James P. Kelly </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Timothy C. Dec </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.25pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Timothy C. Dec </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:0.2pt;">Stefan K.F. Schwabe, M.D., Ph.D. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Jonathan Rubin, MD </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Jonathan Rubin, MD </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Padmanabh P. Bhatt, Ph.D. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:0.2pt;">Padmanabh P. Bhatt, Ph.D. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="white-space:nowrap; text-align:center;"> <span style="letter-spacing:0.2pt;">Padmanabh P. Bhatt, Ph.D. </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Gregory S. Patrick </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Tami Martin, R.N., Esq. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Frank Mottola </span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:0pt; width:0pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:145.47pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Tami Martin, R.N., Esq. </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">James P. Kelly </span> </div> </td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:0pt; width:19.59pt;">​</td> <td style="padding:3.5pt 0pt 1.5pt 0pt; width:116.08pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">—</span> </div> </td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> Jack Khattar <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12.5pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">3.   Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. Amounts in the Inclusion of Equity Values column are set forth in the table further below. </span> </div><table style="width:456pt;height:68.5pt;margin-top:13pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:156.3pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average Summary <br/> Compensation Table <br/> Total for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average Exclusion of <br/> Stock Awards and <br/> Option Awards for <br/> Non-PEO NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average Inclusion of <br/> Equity Values for <br/> Non-PEO NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Compensation <br/> Actually Paid <br/> to Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:156.3pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:13.765pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,806,329</td> <td style="padding:0pt;padding-left:13.765pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:12.835pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:33pt; text-align:right; white-space:nowrap;">(1,175,975<span style="position:absolute;">)</span></td> <td style="padding:0pt;padding-left:12.835pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:13.31pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,061,497</td> <td style="padding:0pt;padding-left:13.31pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,691,851</td> <td style="padding:0pt;padding-left:3.46pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table><div style="text-indent:20pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: </span> </div><table style="width:456pt;height:149.5pt;margin-top:13pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:98.49pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Year-End <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> That <br/> Remained <br/> Unvested as of <br/> Last Day of <br/> Year for <br/> Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Last Day of <br/> Year of <br/> Unvested <br/> Equity <br/> Awards for <br/> Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Vesting-Date <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> that Vested <br/> During Year <br/> for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Vesting <br/> Date of <br/> Unvested <br/> Equity <br/> Awards that <br/> Vested During <br/> Year for <br/> Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Average <br/> Fair <br/> Value at Last <br/> Day of Prior <br/> Year of Equity <br/> Awards <br/> Forfeited <br/> During Year <br/> for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Total − <br/> Average <br/> Inclusion <br/> of <br/> Equity <br/> Values <br/> for Non-PEO <br/> NEOs <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:98.49pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:7.555pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">708,219</td> <td style="padding:0pt;padding-left:7.555pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:7.99pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:24.75pt; text-align:right; white-space:nowrap;">346,240</td> <td style="padding:0pt;padding-left:7.99pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:17.83pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;"><span style="-sec-ix-hidden: hidden-fact-2">—</span></td> <td style="padding:0pt;padding-left:17.83pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:10.49pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:21pt; text-align:right; white-space:nowrap;">21,753</td> <td style="padding:0pt;padding-left:10.49pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:8.975pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:23.25pt; text-align:right; white-space:nowrap;">(14,715<span style="position:absolute;">)</span></td> <td style="padding:0pt;padding-left:8.975pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:2.625pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,061,497</td> <td style="padding:0pt;padding-left:2.625pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12.5pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">3.   Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. Amounts in the Inclusion of Equity Values column are set forth in the table further below. </span> </div><table style="width:456pt;height:59.4999999999999pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:168.39pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Summary <br/> Compensation Table <br/> Total for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Exclusion of <br/> Stock Awards and <br/> Option Awards for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Inclusion of <br/> Equity Values for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Compensation <br/> Actually Paid <br/> to Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:168.39pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:11.265pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">13,278,093</td> <td style="padding:0pt;padding-left:11.265pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:6.29pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:36.75pt; text-align:right; white-space:nowrap;">(11,435,200<span style="position:absolute;">)</span></td> <td style="padding:0pt;padding-left:6.29pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:6.07pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">11,648,605</td> <td style="padding:0pt;padding-left:6.07pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:3.695pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">13,491,498</td> <td style="padding:0pt;padding-left:3.695pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table><div style="text-indent:20pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: </span> </div><table style="width:456pt;height:131.5pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <tr style="line-height:9pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:bold;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:8pt;"> <td style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt; width:100.38pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:-0.16pt;">Year </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Year-End <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> That <br/> Remained <br/> Unvested as <br/> of Last Day of <br/> Year for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Last Day of <br/> Year of <br/> Unvested <br/> Equity <br/> Awards for <br/> Jack Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Vesting-Date <br/> Fair Value of <br/> Equity <br/> Awards <br/> Granted <br/> During Year <br/> that Vested <br/> During Year <br/> for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Change in <br/> Fair Value <br/> from Last Day <br/> of Prior Year <br/> to Vesting <br/> Date of <br/> Unvested <br/> Equity <br/> Awards that <br/> Vested During <br/> Year for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Fair Value at <br/> Last Day of <br/> Prior Year of <br/> Equity Awards <br/> Forfeited <br/> During Year <br/> for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">​</td> <td colspan="4" style="border-bottom:1px solid #000000;padding:0pt 0pt 2.167pt 0pt;"> <div style="text-align:center;"> <span style="letter-spacing:-0.16pt;">Total − <br/> Inclusion <br/> of <br/> Equity <br/> Values <br/> for Jack <br/> Khattar <br/> ($) </span> </div> </td> <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">​</td> </tr> <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="padding:3.25pt 0pt 2.167pt 0pt; width:100.38pt;text-align:left;"> <div style="white-space:nowrap;"> <span style="letter-spacing:0.2pt;">2023 </span> </div> </td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:4.245pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">6,566,381</td> <td style="padding:0pt;padding-left:4.245pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,956,489</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:1.5pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">1,012,900</td> <td style="padding:0pt;padding-left:1.5pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:30.75pt; text-align:right; white-space:nowrap;">2,112,835</td> <td style="padding:0pt;padding-left:4.14pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:19.25pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:7.5pt; text-align:right; white-space:nowrap;"><span style="-sec-ix-hidden: hidden-fact-1">—</span></td> <td style="padding:0pt;padding-left:19.25pt;width:0pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt; width:6pt;">​</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:0pt; text-align:right; ">​</td> <td style="padding:3.25pt 0pt 2.167pt 0pt; min-width:34.5pt; text-align:right; white-space:nowrap;">11,648,605</td> <td style="padding:0pt;padding-left:0pt;width:0pt;">​</td> <td style="padding:0pt; width:0pt;">​</td> </tr> </table> 13278093 -11435200 11648605 13491498 1806329 -1175975 1061497 1691851 6566381 1956489 1012900 2112835 11648605 708219 346240 21753 -14715 1061497 <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">4.   The Peer Group TSR set forth in this table utilizes the Nasdaq Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2023. The comparison assumes $100 was invested for the period starting December 31, 2019, through the end of the listed year in the Company and in the Nasdaq Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance. Cumulative TSR is calculated by dividing (i) the sum of (a) the cumulative amount of any dividends for the measurement period and (b) the change in the company’s share price during the measurement period by (ii) the share price at the beginning of the measurement period. This assumes dividend reinvestment. </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">5.   We determined Gross Product Sales to be the most important financial performance measure used to link Company performance to Compensation Actually Paid to our PEO and Non-PEO NEOs in 2023 and 2022. This performance measure may not have been the most important financial performance measure for years prior and we may determine a different financial performance measure to be the most important financial performance measure in future years. </span> </div> <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;font-size:10pt;"> <span style="letter-spacing:-0.2pt;">Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Company Total Shareholder Return (“TSR”)</span><span style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, the Company’s cumulative TSR over the four most recently completed fiscal years, and the Nasdaq Biotechnology Index TSR over the same period. </span> </div><div style="position:relative;margin-top:8.41pt; width:456pt;"> <img alt="[MISSING IMAGE: bc_companytsr-4c.jpg]" src="bc_companytsr-4c.jpg" style="height: 316px; width: 609px;"/> </div> <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;font-size:10pt;"> <span style="letter-spacing:-0.2pt;">Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Company Total Shareholder Return (“TSR”)</span><span style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </span> </div><div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:normal;font-size:10pt;"> <span style="letter-spacing:0.2pt;">The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, the Company’s cumulative TSR over the four most recently completed fiscal years, and the Nasdaq Biotechnology Index TSR over the same period. </span> </div><div style="position:relative;margin-top:8.41pt; width:456pt;"> <img alt="[MISSING IMAGE: bc_companytsr-4c.jpg]" src="bc_companytsr-4c.jpg" style="height: 316px; width: 609px;"/> </div> <div style="margin-top:4.5pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <span style="letter-spacing:-0.2pt;">Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Net Income</span><span style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <span style="letter-spacing:0.2pt;">The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our Net Income during the four most recently completed fiscal years. </span> </div><div style="position:relative;margin-top:8.41pt; text-align:center; width:456pt;"> <img alt="[MISSING IMAGE: bc_netincome-4c.jpg]" src="bc_netincome-4c.jpg" style="height: 352px; width: 605px;"/> </div> <div style="text-indent:20pt; margin-top:12.01pt; width:456pt; line-height:11.5pt;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <span style="letter-spacing:0.2pt;">Net Income included in the preceding chart is calculated in accordance with GAAP (Generally Accepted Accounting Principles). During 2021, 2022 and 2023, the Company accrued amortization </span> </div><div style="width:456pt; line-height:11.5pt;"> <span style="letter-spacing:0.2pt;">expenses for intangible assets of $30.0 million, $82.6 million and $82.4 million, respectively. The level of amortization of intangible assets increased during 2021 and increased further in 2022 primarily due to the amortization of definitive-lived intangible assets acquired in the US WorldMeds and Adamas acquisitions. </span> </div> <div style="margin-top:12pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;"> <span style="letter-spacing:-0.2pt;">Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Gross Product Sales</span><span style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;"> <span style="letter-spacing:0.2pt;">The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our Gross Product Sales during the four most recently completed fiscal years. </span> </div> <div style="margin-top:12pt; text-align:center; width:456pt; line-height:11.5pt;font-weight:bold;"> <span style="letter-spacing:-0.2pt;">PEO and Average Non-PEO NEO Compensation Actually Paid <br/> Versus Gross Product Sales</span><span style="font-weight:normal;letter-spacing:0.2pt;"> </span> </div> <div style="position:relative;margin-top:9.91pt; text-align:center; width:456pt;"> <img alt="[MISSING IMAGE: bc_productsales-4c.jpg]" src="bc_productsales-4c.jpg" style="height: 345px; width: 605px;"/> </div> <div style="margin-top:16.8pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;"> <span style="letter-spacing:-0.2pt;">Tabular List of Most Important Financial Performance Measures</span><span style="font-style:normal;font-weight:normal;letter-spacing:0.2pt;"> </span> </div> <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;"> <span style="letter-spacing:0.2pt;">The following table presents the financial performance measures that the Company considers the most important in linking Compensation Actually Paid to our PEO and Non-PEO NEOs for 2023 to Company performance. The measures in this table are not ranked. </span> </div> <table style="width:240pt;margin-left:108pt;margin-top:10pt;border-collapse: collapse;border:0.75pt solid #000000; font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="width:0.25pt;padding:0pt;font-size:0pt;line-height:0pt;">​</td> <td style="padding:0pt; width:8pt;">​</td> <td style="padding:7.5pt 0pt 0.5pt 0pt; width:224pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Gross Product Sales </span> </div> </td> <td style="padding:0pt; width:8pt;">​</td> <td style="width:0.25pt;padding:0pt;font-size:0pt;line-height:0pt;">​</td> </tr> <tr style="line-height:10pt;min-height:19.5pt;white-space:nowrap;text-align:center;vertical-align:top;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Times New Roman, Times, serif ;font-size:10pt;"> <td style="width:0.25pt;padding:0pt;font-size:0pt;line-height:0pt;">​</td> <td style="padding:0pt;border-bottom:0.75pt solid #000000; ; width:8pt;">​</td> <td style="border-bottom:0.75pt solid #000000; ;padding:3pt 0pt 8pt 0pt; width:224pt;"> <div style="text-align:center;"> <span style="letter-spacing:0.2pt;">Operating Income</span> </div> </td> <td style="padding:0pt;border-bottom:0.75pt solid #000000; ; width:8pt;">​</td> <td style="width:0.25pt;padding:0pt;font-size:0pt;line-height:0pt;">​</td> </tr> </table> Gross Product Sales Operating Income DEF 14A false 0001356576