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  <element id="supn_IncreaseDecreaseInDeferredLicensingRevenue" name="IncreaseDecreaseInDeferredLicensingRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_StockOptionStockAppreciationRightsMember" name="StockOptionStockAppreciationRightsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsFairValue" name="AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsFairValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AvailableForSaleSecuritiesDebtMaturitiesThreeYearsThroughFourYearsFairValue" name="AvailableForSaleSecuritiesDebtMaturitiesThreeYearsThroughFourYearsFairValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NonRecourseDebtSaleOfFutureRoyaltiesCurrent" name="NonRecourseDebtSaleOfFutureRoyaltiesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" name="NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_InterestExpenseNonRecourseRoyaltyLiability" name="InterestExpenseNonRecourseRoyaltyLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredTaxAssetsRoyaltyRevenue" name="DeferredTaxAssetsRoyaltyRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredTaxLiabilitiesInfringementLegalCost" name="DeferredTaxLiabilitiesInfringementLegalCost" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_StockOptionsStockAppreciationRightsAndEmployeeStockPurchasePlanAwardsMember" name="StockOptionsStockAppreciationRightsAndEmployeeStockPurchasePlanAwardsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NumberOfSettlements" name="NumberOfSettlements" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherCurrentAssets" name="IncreaseDecreaseInPrepaidDeferredExpenseAndOtherCurrentAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_RuneHealthcareLimitedMember" name="RuneHealthcareLimitedMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_MilestonePaymentsDue" name="MilestonePaymentsDue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_EmployeesConsultantsAndAdvisorsMember" name="EmployeesConsultantsAndAdvisorsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_UnsettledPurchaseOfMarketableSecuritiesIncludedInAccruedExpenses" name="UnsettledPurchaseOfMarketableSecuritiesIncludedInAccruedExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_IncomeTaxExpenseOnUncertainTaxPositionAlternateMinimumTax" name="IncomeTaxExpenseOnUncertainTaxPositionAlternateMinimumTax" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_IncomeTaxExpenseOnUncertainTaxPosition" name="IncomeTaxExpenseOnUncertainTaxPosition" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AfectaPharmaceuticalsIncMember" name="AfectaPharmaceuticalsIncMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_PotentialMaximumMilestonePaymentsPayable" name="PotentialMaximumMilestonePaymentsPayable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AvailableForSaleSecuritiesDebtMaturitiesTwoYearsThroughThreeYearsFairValue" name="AvailableForSaleSecuritiesDebtMaturitiesTwoYearsThroughThreeYearsFairValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredTaxLiabilities481aAdjustment" name="DeferredTaxLiabilities481aAdjustment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_TrokendiXRMember" name="TrokendiXRMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_MinimumGuaranteedAmountsOwedToCompany" name="MinimumGuaranteedAmountsOwedToCompany" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NotesFaceValue" name="NotesFaceValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NotesAtEstimatedFairValue" name="NotesAtEstimatedFairValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_PercentageOf0.625ConvertibleSeniorNotesDue2023Member" name="PercentageOf0.625ConvertibleSeniorNotesDue2023Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
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  <element id="supn_DebtInstrumentConvertibleThresholdTradingDaysWasLessThanSpecifiedPercentageOfProductOfLastReportedSalePriceOfCommonStock" name="DebtInstrumentConvertibleThresholdTradingDaysWasLessThanSpecifiedPercentageOfProductOfLastReportedSalePriceOfCommonStock" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DebtInstrumentConvertibleThresholdConsecutiveTradingDaysWasLessThanSpecifiedPercentageOfProductLastReportedSalePriceOfCommonStock" name="DebtInstrumentConvertibleThresholdConsecutiveTradingDaysWasLessThanSpecifiedPercentageOfProductLastReportedSalePriceOfCommonStock" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_PurchasesOfConvertibleNoteHedge" name="PurchasesOfConvertibleNoteHedge" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ConvertibleNotesHedgeMember" name="ConvertibleNotesHedgeMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ClassOfWarrantOrRightNumberOfSharesInWhichHolderCanBeEntitledPerWarrantsAtStrikePrice" name="ClassOfWarrantOrRightNumberOfSharesInWhichHolderCanBeEntitledPerWarrantsAtStrikePrice" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_PercentageOf0.625ConvertibleSeniorNotesDue2023GrantedToInitialPurchasersMember" name="PercentageOf0.625ConvertibleSeniorNotesDue2023GrantedToInitialPurchasersMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_PercentageOf0.625ConvertibleSeniorNotesDue2023OverAllotmentOptionMember" name="PercentageOf0.625ConvertibleSeniorNotesDue2023OverAllotmentOptionMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_PurchasesOfConvertibleNoteHedgesNetOfTax" name="PurchasesOfConvertibleNoteHedgesNetOfTax" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NumberOfProprietaryCommercialProducts" name="NumberOfProprietaryCommercialProducts" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
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  <element id="supn_AccruedSalesDeductionsTextBlock" name="AccruedSalesDeductionsTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ScheduleOfAccruedSalesDeductionsTableTextBlock" name="ScheduleOfAccruedSalesDeductionsTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AccruedProductReturns" name="AccruedProductReturns" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AccruedSalesDeductionsNet" name="AccruedSalesDeductionsNet" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DevelopedIntellectualPropertyMember" name="DevelopedIntellectualPropertyMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DevelopedProductsMember" name="DevelopedProductsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ProductsShelfLife" name="ProductsShelfLife" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NumberOfCommercialProducts" name="NumberOfCommercialProducts" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AccruedRebates" name="AccruedRebates" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_LicenseEventBasedMilestoneMember" name="LicenseEventBasedMilestoneMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_OperatingLeasesFutureMinimumPaymentsDueAfterTwoYears" name="OperatingLeasesFutureMinimumPaymentsDueAfterTwoYears" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AdventKeyWestLlcMember" name="AdventKeyWestLlcMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_OperatingLeasesRentalExpensesAnnualIncreaseInRentalPaymentsPercentage" name="OperatingLeasesRentalExpensesAnnualIncreaseInRentalPaymentsPercentage" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_FinancialInstrumentsOwnedCorporateDebtAtFairValueCurrent" name="FinancialInstrumentsOwnedCorporateDebtAtFairValueCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_OperatingLeasesRentalExpensesInitialFixedMonthlyRentalPayments" name="OperatingLeasesRentalExpensesInitialFixedMonthlyRentalPayments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AssetAcquisitionInitialUpfrontCashPayment" name="AssetAcquisitionInitialUpfrontCashPayment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AssetAcquisitionContingentConsiderationLiability" name="AssetAcquisitionContingentConsiderationLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AssetAcquisitionMaximumPercentageOfCombinedRoyalty" name="AssetAcquisitionMaximumPercentageOfCombinedRoyalty" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AssetAcquisitionResearchAndDevelopmentExpense" name="AssetAcquisitionResearchAndDevelopmentExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AssetAcquisitionPaymentsToAcquireInProcessResearchAndDevelopment" name="AssetAcquisitionPaymentsToAcquireInProcessResearchAndDevelopment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AssetAcquisitionDeferredTaxAsset" name="AssetAcquisitionDeferredTaxAsset" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredTaxAssetAmortization" name="DeferredTaxAssetAmortization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NetOperatingLossCarryforwardUtilized" name="NetOperatingLossCarryforwardUtilized" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredTaxAssetsConvertibleBondHedge" name="DeferredTaxAssetsConvertibleBondHedge" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AcquisitionOfBiscayneNeurotherapeuticsIncMember" name="AcquisitionOfBiscayneNeurotherapeuticsIncMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>
