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  <xsd:element name="ProbabilityWeightedExpectedReturnMethodMember" id="supn_ProbabilityWeightedExpectedReturnMethodMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueRecognitionDevelopmentRevenueMaximumTermOfContracts" id="supn_RevenueRecognitionDevelopmentRevenueMaximumTermOfContracts" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScenarioAxis" id="supn_ScenarioAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScenarioDomain" id="supn_ScenarioDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TermLoanInitialMember" id="supn_TermLoanInitialMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TermLoanAdditionalMember" id="supn_TermLoanAdditionalMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantLiabilityPolicyTextBlock" id="supn_WarrantLiabilityPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantToPurchaseCommonStockMember" id="supn_WarrantToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantToPurchasePreferredStockMember" id="supn_WarrantToPurchasePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProceedsFromIssuanceInitialPublicOfferingGross" id="supn_ProceedsFromIssuanceInitialPublicOfferingGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="OverAllotmentOfSharesDuringThePeriodShares" id="supn_OverAllotmentOfSharesDuringThePeriodShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClassOfWarrantOrRightExercised" id="supn_ClassOfWarrantOrRightExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="ClassOfWarrantOrRightNumberOfSecuritiesIssuedUponExerciseOfWarrants" id="supn_ClassOfWarrantOrRightNumberOfSecuritiesIssuedUponExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="OverAllotmentOfSharesDuringThePeriodValue" id="supn_OverAllotmentOfSharesDuringThePeriodValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentTerm" id="supn_DebtInstrumentTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DeferredRevenueRevenueRecognitionPeriod" id="supn_DeferredRevenueRevenueRecognitionPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
</xsd:schema>





