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  <xs:element id="supn_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCostsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCostsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="supn_EffectiveIncomeTaxRateReconciliationPermanentItemsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationPermanentItemsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_EffectiveIncomeTaxRateReconciliationLossOnInvestmentAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationLossOnInvestmentAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DeferredTaxAssetsOperatingLeaseLiability" abstract="false" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts" abstract="false" name="DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ReconciliationOfValuationAllowanceRollForward" abstract="true" name="ReconciliationOfValuationAllowanceRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_DeferredTaxAssetsValuationAllowanceIncreaseFromAcquisitionAccounting" abstract="false" name="DeferredTaxAssetsValuationAllowanceIncreaseFromAcquisitionAccounting" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DeferredTaxAssetsValuationAllowanceAdditions" abstract="false" name="DeferredTaxAssetsValuationAllowanceAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DeferredTaxAssetsValuationAllowanceReductions" abstract="false" name="DeferredTaxAssetsValuationAllowanceReductions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_MerzAgreementMember" abstract="true" name="MerzAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_PurchaseCommitmentAnnualMinimumAmountCommitted" abstract="false" name="PurchaseCommitmentAnnualMinimumAmountCommitted" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LeaseLiabilitiesCurrentAbstract" abstract="true" name="LeaseLiabilitiesCurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_LeaseLiabilitiesNoncurrentAbstract" abstract="true" name="LeaseLiabilitiesNoncurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_OperatingLeaseCostAbstract" abstract="true" name="OperatingLeaseCostAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_OperatingLeaseFixedLeaseCost" abstract="false" name="OperatingLeaseFixedLeaseCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_OperatingLeaseVariableLeaseCost" abstract="false" name="OperatingLeaseVariableLeaseCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_SPN820Member" abstract="true" name="SPN820Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_SPN817Member" abstract="true" name="SPN817Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ZURZUVAEMember" abstract="true" name="ZURZUVAEMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_EarlyStageProgramAndOtherMember" abstract="true" name="EarlyStageProgramAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ExternalResearchAndDevelopmentExpense" abstract="false" name="ExternalResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_InternalResearchAndDevelopmentExpense" abstract="false" name="InternalResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_RevenueRemainingPerformanceObligationTypeAxis" abstract="true" name="RevenueRemainingPerformanceObligationTypeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="supn_RevenueRemainingPerformanceObligationTypeDomain" abstract="true" name="RevenueRemainingPerformanceObligationTypeDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AchievementOfSpecifiedRegulatoryMilestonesMember" abstract="true" name="AchievementOfSpecifiedRegulatoryMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AchievementOfSpecifiedCommercializationMilestonesMember" abstract="true" name="AchievementOfSpecifiedCommercializationMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AchievementOfSpecifiedNetSalesMilestonesMember" abstract="true" name="AchievementOfSpecifiedNetSalesMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_BiogenCollaborationAgreementMember" abstract="true" name="BiogenCollaborationAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_RevenueRemainingPerformanceObligationVariableConsiderationAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_AllowanceForExpectedSalesDeductions" abstract="false" name="AllowanceForExpectedSalesDeductions" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LabEquipmentAndFurnitureMember" abstract="true" name="LabEquipmentAndFurnitureMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AccruedManufacturingExpensesCurrent" abstract="false" name="AccruedManufacturingExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_AccruedResearchAndDevelopmentExpensesCurrent" abstract="false" name="AccruedResearchAndDevelopmentExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_AccruedRebates" abstract="false" name="AccruedRebates" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_AccruedProductReturns" abstract="false" name="AccruedProductReturns" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_NAMENDAXRNamzaricQuiTamLitigationMember" abstract="true" name="NAMENDAXRNamzaricQuiTamLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_MergerAgreementMember" abstract="true" name="MergerAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_DerivativeLitigationMember" abstract="true" name="DerivativeLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_JackKhattarMember" abstract="true" name="JackKhattarMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_PadmanabhBhattMember" abstract="true" name="PadmanabhBhattMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_SaleOfCommonStockIndirectlyBeneficiallyOwnedThroughTheKBTTrustMember" abstract="true" name="SaleOfCommonStockIndirectlyBeneficiallyOwnedThroughTheKBTTrustMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
