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  <xs:element id="supn_SPN830FDAAcceptanceMilestoneMember" abstract="true" name="SPN830FDAAcceptanceMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_PatentDefenseCostsMember" abstract="true" name="PatentDefenseCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_OxtellarXRMember" abstract="true" name="OxtellarXRMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_RevenueFromRoyaltyAgreement" abstract="false" name="RevenueFromRoyaltyAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_McKessonMember" abstract="true" name="McKessonMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ContingentConsiderationDisclosureTextBlock" abstract="false" name="ContingentConsiderationDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="supn_SPN830FirstCommercialAndSaleMember" abstract="true" name="SPN830FirstCommercialAndSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationArrangementsConsecutiveTwelveMonthNetSalesThresholdPeriodTwo" abstract="false" name="BusinessCombinationContingentConsiderationArrangementsConsecutiveTwelveMonthNetSalesThresholdPeriodTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiabilityNoncurrent" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_TrokendiXrMember" abstract="true" name="TrokendiXrMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_NonRecourseLiabilityNoncurrent" abstract="false" name="NonRecourseLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LabEquipmentAndFurnitureMember" abstract="true" name="LabEquipmentAndFurnitureMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_NonCashCapitalizedCostOfIntangibleAssets" abstract="false" name="NonCashCapitalizedCostOfIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_NavitorPharmaceuticalsIncMember" abstract="true" name="NavitorPharmaceuticalsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_MDDUSEnterprisesLLCFormerlyUSWMEnterprisesMember" abstract="true" name="MDDUSEnterprisesLLCFormerlyUSWMEnterprisesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ThreeMajorCustomersMember" abstract="true" name="ThreeMajorCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_LesseeOperatingAndFinanceLeaseBalanceSheetDisclosureTableTextBlock" abstract="false" name="LesseeOperatingAndFinanceLeaseBalanceSheetDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="supn_LeaseLiabilitiesNoncurrentAbstract" abstract="true" name="LeaseLiabilitiesNoncurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFinancialIdentifiableAssets" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFinancialIdentifiableAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ConversionCircumstanceOneMember" abstract="true" name="ConversionCircumstanceOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_PurchaseCommitmentAnnualMinimumAmountCommitted" abstract="false" name="PurchaseCommitmentAnnualMinimumAmountCommitted" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ConversionCircumstanceTwoMember" abstract="true" name="ConversionCircumstanceTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
