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  <xsd:element name="PrepaymentPeriodThereafterMember" id="supn_PrepaymentPeriodThereafterMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProbabilityWeightedExpectedReturnMethodMember" id="supn_ProbabilityWeightedExpectedReturnMethodMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueRecognitionDevelopmentRevenueMaximumTermOfContracts" id="supn_RevenueRecognitionDevelopmentRevenueMaximumTermOfContracts" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScenarioAxis" id="supn_ScenarioAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScenarioDomain" id="supn_ScenarioDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TermLoanInitialMember" id="supn_TermLoanInitialMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TermLoanAdditionalMember" id="supn_TermLoanAdditionalMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantLiabilityPolicyTextBlock" id="supn_WarrantLiabilityPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantToPurchaseCommonStockMember" id="supn_WarrantToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantToPurchasePreferredStockMember" id="supn_WarrantToPurchasePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OverAllotmentOfSharesDuringPeriodShares" id="supn_OverAllotmentOfSharesDuringPeriodShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OverAllotmentOfSharesDuringPeriodValue" id="supn_OverAllotmentOfSharesDuringPeriodValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="NumberOfProductCandidatesForAttainingMarketingApproval" id="supn_NumberOfProductCandidatesForAttainingMarketingApproval" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MinimumNumberOfProductsUntilEstablishmentOfWhichInMarketplaceOperatingLossesIsExpectedToContinue" id="supn_MinimumNumberOfProductsUntilEstablishmentOfWhichInMarketplaceOperatingLossesIsExpectedToContinue" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ReverseStockSplitPolicyTextBlock" id="supn_ReverseStockSplitPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BasisOfPresentationAbstract" id="supn_BasisOfPresentationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisposalGroupsIncludingDiscontinuedOperationsPotentialMilestonePaymentNumberOfDaysFromOccurrenceOfConditions" id="supn_DisposalGroupsIncludingDiscontinuedOperationsPotentialMilestonePaymentNumberOfDaysFromOccurrenceOfConditions" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisposalGroupsIncludingDiscontinuedOperationsMilestonePaymentConditionOneMinimumRoyaltyPaymentToBeReceivedByPurchaser" id="supn_DisposalGroupsIncludingDiscontinuedOperationsMilestonePaymentConditionOneMinimumRoyaltyPaymentToBeReceivedByPurchaser" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DisposalGroupsIncludingDiscontinuedOperationsMilestonePaymentConditionTwoMinimumProceeds" id="supn_DisposalGroupsIncludingDiscontinuedOperationsMilestonePaymentConditionTwoMinimumProceeds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DisposalGroupsIncludingDiscontinuedOperationsPurchasePriceDeterminationMinimumNumberOfBiddersInvolvedInCompetitiveBiddingProcess" id="supn_DisposalGroupsIncludingDiscontinuedOperationsPurchasePriceDeterminationMinimumNumberOfBiddersInvolvedInCompetitiveBiddingProcess" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisposalGroupsIncludingDiscontinuedOperationsServicingAgreementAnnualServicingFeeToBeReceived" id="supn_DisposalGroupsIncludingDiscontinuedOperationsServicingAgreementAnnualServicingFeeToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationSalesConsiderationCashPayment" id="supn_DisposalGroupIncludingDiscontinuedOperationSalesConsiderationCashPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesAllowanceForTenantAndCapitalImprovement" id="supn_OperatingLeasesAllowanceForTenantAndCapitalImprovement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesBaseAnnualRentIncreasePercentage" id="supn_OperatingLeasesBaseAnnualRentIncreasePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesOptionalLeaseExtensionPeriod" id="supn_OperatingLeasesOptionalLeaseExtensionPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesAdditionalAllowanceForTenantAndCapitalImprovement" id="supn_OperatingLeasesAdditionalAllowanceForTenantAndCapitalImprovement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="OperatingLeasesAllowanceForTenantAndCapitalImprovementCapitalized" id="supn_OperatingLeasesAllowanceForTenantAndCapitalImprovementCapitalized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DefinedContributionPlanEligibilityMinimumAge" id="supn_DefinedContributionPlanEligibilityMinimumAge" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DefinedContributionPlanMaximumEmployeeContributionPercentage" id="supn_DefinedContributionPlanMaximumEmployeeContributionPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DefinedContributionPlanPercentageVestingOfEmployeeContribution" id="supn_DefinedContributionPlanPercentageVestingOfEmployeeContribution" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DefinedContributionPlanEmployerMatchLevelOne" id="supn_DefinedContributionPlanEmployerMatchLevelOne" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DefinedContributionPlanEmployerMatchEmployeeContributionLevelOne" id="supn_DefinedContributionPlanEmployerMatchEmployeeContributionLevelOne" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DefinedContributionPlanEmployerMatchLevelTwo" id="supn_DefinedContributionPlanEmployerMatchLevelTwo" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EmployerMatchEmployeeContributionLevelTwo" id="supn_EmployerMatchEmployeeContributionLevelTwo" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DefinedContributionPlanMaximumDiscretionaryEmployerContributionPercentage" id="supn_DefinedContributionPlanMaximumDiscretionaryEmployerContributionPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShireLLCMember" id="supn_ShireLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RoyaltyOpportunitiesSArlMember" id="supn_RoyaltyOpportunitiesSArlMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RelatedPartyTransactionRoyaltyPaymentReceived" id="supn_RelatedPartyTransactionRoyaltyPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementAdditionalMilestonePaymentsToBeReceived" id="supn_CollaborativeArrangementAdditionalMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementExpirationPeriodFromFirstCommercialSaleOfProduct" id="supn_CollaborativeArrangementExpirationPeriodFromFirstCommercialSaleOfProduct" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementAmountReceivedToBeRecognizedAsRevenueOnStraightLineBasisOverObligationPeriod" id="supn_CollaborativeArrangementAmountReceivedToBeRecognizedAsRevenueOnStraightLineBasisOverObligationPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="CollaborationAgreementSubstantiveObligationPeriod" id="supn_CollaborationAgreementSubstantiveObligationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementAdditionalMilestonePaymentsMaximum" id="supn_CollaborativeArrangementAdditionalMilestonePaymentsMaximum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementMilestonePaymentsToBeReceivedUponSatisfactionOfDevelopmentMilestonesOfAdditionalProductsForSecondIndication" id="supn_CollaborativeArrangementMilestonePaymentsToBeReceivedUponSatisfactionOfDevelopmentMilestonesOfAdditionalProductsForSecondIndication" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementMilestonePaymentsToBeReceivedUponSatisfactionOfDevelopmentMilestonesOfProduct" id="supn_CollaborativeArrangementMilestonePaymentsToBeReceivedUponSatisfactionOfDevelopmentMilestonesOfProduct" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockSharesIssuedAcquisitions" id="supn_PreferredStockSharesIssuedAcquisitions" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ConvertiblePreferredStockInitialConversionRatio" id="supn_ConvertiblePreferredStockInitialConversionRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ConvertiblePreferredStockConversionRatioAfterEffectOfReverseStockSplit" id="supn_ConvertiblePreferredStockConversionRatioAfterEffectOfReverseStockSplit" type="xbrli:pureItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CommonStockConversionRatioOfReverseStockSplit" id="supn_CommonStockConversionRatioOfReverseStockSplit" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockVotingRightsNumberOfDirectorsThatCanBeElected" id="supn_PreferredStockVotingRightsNumberOfDirectorsThatCanBeElected" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PreferredStockMinimumVotingRightsPercentageRequiredForMaterialChanges" id="supn_PreferredStockMinimumVotingRightsPercentageRequiredForMaterialChanges" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfOptionsGrantedTableTextBlock" id="supn_ScheduleOfOptionsGrantedTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockPlan2005Member" id="supn_StockPlan2005Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EquityIncentivePlan2012Member" id="supn_EquityIncentivePlan2012Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingNumberOfInstallmentsFromFirstAnniversaryOfGrantDate" id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingNumberOfInstallmentsFromFirstAnniversaryOfGrantDate" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfProductCandidatesForAttainingRegulatoryApproval" id="supn_NumberOfProductCandidatesForAttainingRegulatoryApproval" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FiniteLivedIntangibleAssetsEstimatedAnnualAggregateAmortizationExpense" id="supn_FiniteLivedIntangibleAssetsEstimatedAnnualAggregateAmortizationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="RevisionOfCommercialPlanNumberOfLateStageEpilepsyProductCandidates" id="supn_RevisionOfCommercialPlanNumberOfLateStageEpilepsyProductCandidates" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfProductCandidatesWhichReceivedTentativeApproval" id="supn_NumberOfProductCandidatesWhichReceivedTentativeApproval" type="xbrli:integerItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="VestingAxis" id="supn_VestingAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProceedsFromIssuanceInitialPublicOfferingNet" id="supn_ProceedsFromIssuanceInitialPublicOfferingNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ProceedsFromIssuanceOfCommonStockNet" id="supn_ProceedsFromIssuanceOfCommonStockNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityExerciseOfWarrants" id="supn_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PeriodSubsequentToExpiryDateForAcceptingDamagedOrDefectiveProduct" id="supn_PeriodSubsequentToExpiryDateForAcceptingDamagedOrDefectiveProduct" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClassOfWarrantOrRightNumberOfWarrantsExercised" id="supn_ClassOfWarrantOrRightNumberOfWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="ClassOfWarrantOrRightNumberOfSharesIssuedOnWarrantsExercised" id="supn_ClassOfWarrantOrRightNumberOfSharesIssuedOnWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="StockOptionsAndEmployeeStockPurchasePlanAwardsMember" id="supn_StockOptionsAndEmployeeStockPurchasePlanAwardsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfProprietaryProductsInClinicalDevelopment" id="supn_NumberOfProprietaryProductsInClinicalDevelopment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedClinicalTrialCostsCurrent" id="supn_AccruedClinicalTrialCostsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="StockIssuedDuringPeriodValueStockWarrantsExercised" id="supn_StockIssuedDuringPeriodValueStockWarrantsExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedDuringPeriodSharesStockWarrantsExercised" id="supn_StockIssuedDuringPeriodSharesStockWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="InterestPayableReclassifiedToAccountsPayableAndAccruedExpenses" id="supn_InterestPayableReclassifiedToAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ConversionOfWarrantsAmountConverted" id="supn_ConversionOfWarrantsAmountConverted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IssuanceOfWarrant" id="supn_IssuanceOfWarrant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ExerciseOfWarrantsAmountExercised" id="supn_ExerciseOfWarrantsAmountExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="AccruedCompensationReclassifiedToAccountsPayableAndAccruedExpenses" id="supn_AccruedCompensationReclassifiedToAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="InventoryWorkInProcessAndRawMaterialsNetOfReservesForWhichTenativeApprovalReceivedFromFDA" id="supn_InventoryWorkInProcessAndRawMaterialsNetOfReservesForWhichTenativeApprovalReceivedFromFDA" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
</xsd:schema>





