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  <xsd:element id="supn_ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" name="ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_SelfInsuranceLiabilitiesPolicyTextBlock" name="SelfInsuranceLiabilitiesPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_SelfInsuranceLiability" name="SelfInsuranceLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" name="StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" name="StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_StockOptionStockAppreciationRightsMember" name="StockOptionStockAppreciationRightsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAdjustedBalance" name="StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAdjustedBalance" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="supn_TenantReceivableLeasesAdditionalAllowanceForTenantAndCapitalImprovement" name="TenantReceivableLeasesAdditionalAllowanceForTenantAndCapitalImprovement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="supn_ThresholdLimitForMedicalClaim" name="ThresholdLimitForMedicalClaim" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_TopThreeWholesalePharmaceuticalDistributorsMember" name="TopThreeWholesalePharmaceuticalDistributorsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_TrokendiXrMember" name="TrokendiXrMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
