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  <xsd:element name="StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" id="supn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" id="supn_StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FairValueAssumptionsCreditSpread" id="supn_FairValueAssumptionsCreditSpread" type="num:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementsTransactionsAxis" id="supn_CollaborativeArrangementsTransactionsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementsTransactionsDomain" id="supn_CollaborativeArrangementsTransactionsDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentConvertibleThresholdConsecutiveTradingDaysPriorToConversionDateDuringWhichPrincipalAmountOfNotesForSuchTradingDayWasLessThanSpecifiedPercentageOfProductLastReportedSalePriceOfCommonStock" id="supn_DebtInstrumentConvertibleThresholdConsecutiveTradingDaysPriorToConversionDateDuringWhichPrincipalAmountOfNotesForSuchTradingDayWasLessThanSpecifiedPercentageOfProductLastReportedSalePriceOfCommonStock" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentConvertiblePeriodFromNoticeDateWithinWhichNotesHolderCanExerciseTheirRightToExchangeNotes" id="supn_DebtInstrumentConvertiblePeriodFromNoticeDateWithinWhichNotesHolderCanExerciseTheirRightToExchangeNotes" type="xbrli:durationItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedDuringPeriodValueConversionOfConvertibleNotes" id="supn_StockIssuedDuringPeriodValueConversionOfConvertibleNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedDuringPeriodSharesConversionOfConvertibleNotes" id="supn_StockIssuedDuringPeriodSharesConversionOfConvertibleNotes" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockOptionsStockAppreciationRightsAndNonVestedStockOptionsMember" id="supn_StockOptionsStockAppreciationRightsAndNonVestedStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element id="supn_OperatingLossCarryforwardsTaxAffected" name="OperatingLossCarryforwardsTaxAffected" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="DeferredTaxLiabilitiesDebtDiscountOnConvertibleNotes" id="supn_DeferredTaxLiabilitiesDebtDiscountOnConvertibleNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenuesNetMember" id="supn_RevenuesNetMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CustomerAMember" id="supn_CustomerAMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CustomerBMember" id="supn_CustomerBMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CustomerCMember" id="supn_CustomerCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element id="supn_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeatureNetOfIssuanceCosts" name="AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeatureNetOfIssuanceCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_FairValueOfInterestMakeWholeDerivative" name="FairValueOfInterestMakeWholeDerivative" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_IncrementalCommonSharesAttributableToStockOptionsStockAppreciationRightsAndNonVestedStockOptions" name="IncrementalCommonSharesAttributableToStockOptionsStockAppreciationRightsAndNonVestedStockOptions" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_GainsLossesOnExtinguishmentOfOutstandingDebt" name="GainsLossesOnExtinguishmentOfOutstandingDebt" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_IncreaseDecreaseInFairValueDerivativeLiabilities" name="IncreaseDecreaseInFairValueDerivativeLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_RevenueFromRoyaltyAgreement" name="RevenueFromRoyaltyAgreement" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" name="ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DebtInstrumentConvertibleNumberOfEquityInstrumentInShares" name="DebtInstrumentConvertibleNumberOfEquityInstrumentInShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DebtInstrumentConvertibleThresholdTradingDaysPriorToConversionDateDuringWhichPrincipalAmountOfNotesForSuchTradingDayWasLessThanSpecifiedPercentageOfProductOfLastReportedSalePriceOfCommonStock" name="DebtInstrumentConvertibleThresholdTradingDaysPriorToConversionDateDuringWhichPrincipalAmountOfNotesForSuchTradingDayWasLessThanSpecifiedPercentageOfProductOfLastReportedSalePriceOfCommonStock" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AccruedSalesDeduction" name="AccruedSalesDeduction" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_IncrementalCommonSharesAttributableToSettlementOfInterestMakeWholeDerivates" name="IncrementalCommonSharesAttributableToSettlementOfInterestMakeWholeDerivates" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_OperatingLeasesAmountAvailableForTenantImprovements" name="OperatingLeasesAmountAvailableForTenantImprovements" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NetOperatingLossForCurrentYear" name="NetOperatingLossForCurrentYear" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_GainsLossesOnExtinguishmentOfOutstandingDebtAsIfConverted" name="GainsLossesOnExtinguishmentOfOutstandingDebtAsIfConverted" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_OperatingLossCarryforwardsAvailableAmountInFiveSucceedingYears" name="OperatingLossCarryforwardsAvailableAmountInFiveSucceedingYears" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_UnrecognizedTaxBenefitsChangeInTaxRates" name="UnrecognizedTaxBenefitsChangeInTaxRates" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AllowanceForExpectedSalesDeductions" name="AllowanceForExpectedSalesDeductions" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_TaxCreditCarryForwardAvailableAmountInFutureYears" name="TaxCreditCarryForwardAvailableAmountInFutureYears" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_SalesDeductionsMember" name="SalesDeductionsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeatureAndDebtDiscount" name="AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeatureAndDebtDiscount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NonCashCapitalizedCostOfIntangibleAssets" name="NonCashCapitalizedCostOfIntangibleAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_SalesReturnPeriodPriorToExpiration" name="SalesReturnPeriodPriorToExpiration" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_IncreaseDecreaseInAccruedSalesDeductions" name="IncreaseDecreaseInAccruedSalesDeductions" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NetOperatingLossCurrentUtilizedPerYearInFuture" name="NetOperatingLossCurrentUtilizedPerYearInFuture" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AccountingStandardsUpdate201517Member" name="AccountingStandardsUpdate201517Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredLegalFeesPolicyTextBlock" name="DeferredLegalFeesPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_FederalIncomeTaxesPaid" name="FederalIncomeTaxesPaid" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_OxtellarXrLitigationMember" name="OxtellarXrLitigationMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredFinancingCostsPolicyTextBlock" name="DeferredFinancingCostsPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DebtConversionConvertedInstrumentAndInterestMakeWholeAmount" name="DebtConversionConvertedInstrumentAndInterestMakeWholeAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NonRecourseDebtSaleOfFutureRoyaltiesCurrent" name="NonRecourseDebtSaleOfFutureRoyaltiesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" name="NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_InterestExpenseNonRecourseRoyaltyLiability" name="InterestExpenseNonRecourseRoyaltyLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_DeferredTaxAssetsRoyaltyRevenue" name="DeferredTaxAssetsRoyaltyRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ProceedsFromSaleOfFutureRoyalties" name="ProceedsFromSaleOfFutureRoyalties" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_AccountingStandardsUpdate201503Member" name="AccountingStandardsUpdate201503Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="supn_ProFormaAdjustmentMember" name="ProFormaAdjustmentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>