Document and Entity Information Statement [Table] Statement [Line Items] Statement Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus Consolidated Balance Sheets Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of year Cash and cash equivalents at beginning of year Cash and cash equivalents Marketable Securities, Current Marketable securities Accounts Receivable, Net, Current Accounts receivable, net Inventory, Net Inventories, net Total inventories Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Total current assets Marketable Securities, Noncurrent Long term marketable securities Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Deferred Costs, Noncurrent Deferred legal fees Intangible Assets, Net (Excluding Goodwill) Intangible assets, net Net book value of intangible assets Other Assets, Noncurrent Other non-current assets Deferred Tax Assets, Net, Noncurrent Deferred income taxes Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Represent the amount of accrued sales deduction. Accrued Sales Deduction Accrued sales deductions Accrued Liabilities, Current Accrued expenses Total Current portion of debt due within one year or the normal operating cycle, if longer, related to the sale of future royalties, for which the creditor does not have general recourse to the debtor but rather has recourse only to the property used for collateral in the transaction or other specific property. Non Recourse Debt Sale of Future Royalties Current Non-recourse liability related to sale of future royalties, current portion Represents the carrying amount of licensing consideration received or receivable, as of the balance sheet date, on potential earnings that were not recognized as revenue in conformity with GAAP, and which are expected to be recognized as such within one year or the normal operating cycle, if longer. Deferred Revenue Licensing Current Deferred licensing revenue Liabilities, Current Total current liabilities Represents the licensing revenue received, but not recognized for financial reporting purposes, which is anticipated to be recognized for financial reporting purposes more than one year from the reporting date or one operating cycle, if longer. Deferred Revenue Licensing Noncurrent Deferred licensing revenue, net of current portion Convertible Notes Payable, Noncurrent Carrying value of the convertible notes Remaining outstanding balance Convertible notes, net Noncurrent portion of debt, net of the amount due within one year or the normal operating cycle, if longer, related to the sale of future royalties, for which the creditor does not have general recourse to the debtor but rather has recourse only to the property used for collateral in the transaction or other specific property. Non Recourse Debt Sale of Future Royalties Noncurrent Non-recourse liability related to sale of future royalties, long term Other Liabilities, Noncurrent Other non-current liabilities Derivative Liability, Noncurrent Derivative liabilities Liabilities Total liabilities Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Common Stock, Value, Issued Common stock, $0.001 par value, 130,000,000 shares authorized December 31, 2016 and 2015; 49,971,267 and 49,004,674 shares issued and outstanding at December 31, 2016 and 2015, respectively Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss, net of tax Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Ending balance Beginning balance Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding Consolidated Statements of Operations Revenues [Abstract] Revenue Revenue, Net Revenue Net product sales Royalty Revenue Royalty revenue Licenses Revenue Licensing revenue Revenues Total revenue Costs and Expenses [Abstract] Costs and expenses Cost of Goods Sold Cost of product sales Research and Development Expense Research and development Selling, General and Administrative Expense Selling, general and administrative Costs and Expenses Total costs and expenses Total costs and expenses Operating Income (Loss) Operating income (loss) Nonoperating Income (Expense) [Abstract] Other income (expense) Investment Income, Interest Interest income Interest Expense Interest expense Interest expense Interest incurred in the period on the non-recourse sale of future royalty liability arrangement that was charged against earnings. Interest Expense Non Recourse Royalty Liability Interest expense-nonrecourse liability related to sale of future royalties Noncash interest expense on nonrecourse liability related to sale of future royalties Noncash interest expense Gain (Loss) on Derivative Instruments, Net, Pretax Changes in fair value of derivative liabilities Gains (Losses) on Extinguishment of Debt Loss on extinguishment of debt Loss on extinguishment of debt Other Nonoperating Income (Expense) Other (loss) income Nonoperating Income (Expense) Total other expense Income (Loss) from Continuing Operations before Income Taxes, Extraordinary Items, Noncontrolling Interest Earnings (loss) before income taxes Income Tax Expense (Benefit) Income tax (benefit) expense Income tax (benefit)/expense Net Income (Loss) Attributable to Parent Net income Net income (loss) Net income (loss) Earnings Per Share, Basic Net income (loss) per share, basic Basic (in dollars per share) Earnings Per Share, Diluted Diluted (in dollars per share) Net income (loss) per share, diluted Weighted Average Number of Shares Outstanding, Diluted [Abstract] Weighted-average number of common shares outstanding: Weighted Average Number of Shares Outstanding, Basic Basic (in shares) Weighted average shares outstanding, basic Weighted Average Number of Shares Outstanding, Diluted Diluted (in shares) Weighted average shares outstanding, diluted Consolidated Statements of Comprehensive Income (Loss) Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income (loss): Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Unrealized net gain (loss) on marketable securities, net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Other comprehensive income (loss): Other comprehensive income (loss) Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive income (loss) Consolidated Statements of Changes in Stockholder's Equity Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common Stock Additional Paid In Capital [Member] Additional Paid-in Capital Accumulated Other Comprehensive Income [Member] Accumulated Other Comprehensive Income (Loss) Retained Earnings [Member] Accumulated Deficit Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Shares, Outstanding Ending balance (in shares) Beginning balance (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Share-based compensation Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of employee stock purchase plan shares Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of employee stock purchase plan shares (in shares) Value of stock issued as a result of the exercise of stock options and warrants. Stock Issued During Period Value Stock Options and Warrants Exercised Exercise of stock options Number of share options and warrants (or share units) exercised during the current period. Stock Issued During Period Shares Stock Options and Warrants Exercised Exercise of stock options (in shares) Value of stock issued during the period upon the conversion of convertible notes. Stock Issued During Period Value Conversion of Convertible Notes Equity issued on conversion of convertible notes The number of shares issued during the period upon the conversion of convertible notes. Stock Issued During Period Shares Conversion of Convertible Notes Equity issued on conversion of convertible notes (in shares) Stock Issued During Period, Value, Conversion of Convertible Securities Exercise of warrants Stock Issued During Period, Shares, Conversion of Convertible Securities Exercise of warrants (in shares) Adjustments to Additional Paid in Capital, Other Other Consolidated Statements of Cash Flows Net Cash Provided by (Used in) Operating Activities [Abstract] Cash flows from operating activities Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: Unrealized Gain (Loss) on Derivatives Change in fair value of derivative liability Marketable Securities, Unrealized Gain (Loss), Excluding Other than Temporary Impairments Unrealized loss on marketable securities Depreciation, Depletion and Amortization Depreciation and amortization Amortization of Financing Costs and Discounts Amortization of deferred financing costs and debt discount Accretion of debt discount and deferred financing costs Represents revenue from the sale of certain royalty and milestone rights. Revenue From Royalty Agreement Non-cash royalty revenue Share-based Compensation Share-based compensation expense Deferred Income Tax Expense (Benefit) Deferred income tax benefit Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Inventories Inventories Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Accounts Payable Accounts payable The increase (decrease) during the reporting period in the aggregate amount of accrued sales deduction. Increase Decrease In Accrued Sales Deductions Accrued sales deductions Increase (Decrease) in Accrued Liabilities Accrued expenses Represents the increase (decrease) during the reporting period, excluding the portion taken into income, in the liability reflecting product revenue yet to be earned for which cash or other forms of consideration was received or recorded as a receivable, net of expected costs and the cost of product shipped. Increase (Decrease) in Deferred Product Revenue Net Deferred product revenue, net Represents the increase (decrease) during the reporting period, excluding the portion taken into income, in the liability reflecting licensing revenue yet to be earned for which cash or other forms of consideration was received or recorded as a receivable. Increase (Decrease) in Deferred Licensing Revenue Deferred licensing revenue Increase (Decrease) in Other Noncurrent Liabilities Other non-current liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities Payments to Acquire Marketable Securities Purchases of marketable securities Proceeds from Sale and Maturity of Marketable Securities Sales and maturities of marketable securities Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Payments to Acquire Intangible Assets Deferred legal fees Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Cash flows from financing activities Proceeds from Issuance of Common Stock Proceeds from issuance of common stock Gross cash proceeds from sale of common stock in a follow-on offering Repayments of Convertible Debt Cash settlement of debt to equity conversion The cash inflow from sale of future royalties. Proceeds From Sale of Future Royalties Proceeds from sale of future royalties Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Cash and Cash Equivalents, Period Increase (Decrease) Net change in cash and cash equivalents Supplemental Cash Flow Information [Abstract] Supplemental cash flow information: Interest Paid Cash paid for interest Noncash Investing and Financing Items [Abstract] Noncash financial activity: The value of the financial instrument(s) that the original debt is being converted into in a noncash (or part noncash) transaction as well as the interest make-whole. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. Debt Conversion, Converted Instrument And Interest Make Whole Amount Conversion of convertible notes and interest make-whole The value of warrants exercise in a noncash (or part noncash) transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments during the period. Part noncash refers to that portion of the transaction not resulting in cash receipts or cash payments during the period. Exercise of Warrants Amount Exercised Exercise of warrants Represents the non cash expenses related to intangible assets that were capitalized and shown within accrued expenses. Non Cash Capitalized Cost Of Intangible Assets Deferred legal fees included in accounts payable and accrued expenses Organization and Nature of Operations Nature of Operations [Text Block] Organization and Nature of Operations Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Fair Value of Financial Instruments Inventories Inventory Disclosure [Text Block] Inventories Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Property and Equipment No definition available. Deferred Legal Fees and Intangible Assets The entire disclosure for all or part of the information related to intangible assets and deferred legal fees. Intangible Assets And Deferred Legal Fees Disclosure [Text Block] Deferred Legal Fees and Intangible Assets Accrued Expenses Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued Expenses Convertible Senior Secured Notes Long-term Debt [Text Block] Convertible Senior Secured Notes Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Stockholders' Equity Share-Based Payments Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Share-Based Payments Earnings per Share Earnings Per Share [Text Block] Earnings per Share Income Taxes Income Tax Disclosure [Text Block] Income Taxes Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Employee Benefit Plan Pension and Other Postretirement Benefits Disclosure [Text Block] Employee Benefit Plan Collaboration Agreements Collaborative Arrangement Disclosure [Text Block] Collaboration Agreements Quarterly Financial Information (unaudited) Quarterly Financial Information [Text Block] Quarterly Financial Information (unaudited) Subsequent Events Subsequent Events [Text Block] Subsequent Events Basis of Accounting, Policy [Policy Text Block] Basis of Presentation Use of Estimates, Policy [Policy Text Block] Use of Estimates Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Marketable Securities, Policy [Policy Text Block] Marketable Securities Trade and Other Accounts Receivable, Policy [Policy Text Block] Accounts Receivable, net Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Inventory, Policy [Policy Text Block] Inventory Property, Plant and Equipment, Policy [Policy Text Block] Property and Equipment Represent the disclosure of accounting policy for the deferred legal fees. Deferred Legal Fees [Policy Text Block] Deferred Legal Fees Intangible Assets, Finite-Lived, Policy [Policy Text Block] Intangible Assets Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Impairment of Long-Lived Assets Represent the disclosure of accounting policy for the deferred financing costs. Deferred Financing Costs [Policy Text Block] Deferred Financing Costs Disclosure of accounting policy for preclinical study and clinical trial accruals and deferred advance payments. Preclinical Study and Clinical Trial Accruals and Deferred Advance Payments [Policy Text Block] Preclinical Study and Clinical Trial Accruals Disclosure of accounting policy of sales of products. Revenue Recognition Sales Of Products [Policy Text Block] Revenue from Product Sales Revenue Recognition, Revenue Reductions [Policy Text Block] Sales Deductions