0000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 0010 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 0015 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0020 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 0030 - Statement - Consolidated Statements of Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 0040 - Statement - Consolidated Statements of Changes in Stockholder's Equity link:presentationLink link:calculationLink link:definitionLink 0045 - Statement - Consolidated Statements of Changes in Stockholder's Equity (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0050 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1010 - Disclosure - Organization and Nature of Operations link:presentationLink link:calculationLink link:definitionLink 1020 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 1030 - Disclosure - Fair Value of Financial Instruments link:presentationLink link:calculationLink link:definitionLink 1040 - Disclosure - Inventories link:presentationLink link:calculationLink link:definitionLink 1050 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 1060 - Disclosure - Intangible Assets link:presentationLink link:calculationLink link:definitionLink 1070 - Disclosure - Accrued Liabilities link:presentationLink link:calculationLink link:definitionLink 1080 - Disclosure - Convertible Senior Secured Notes link:presentationLink link:calculationLink link:definitionLink 1090 - Disclosure - Sale of TCD Royalty Sub Reported as Discontinued Operations link:presentationLink link:calculationLink link:definitionLink 1100 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 1110 - Disclosure - Share-Based Payments link:presentationLink link:calculationLink link:definitionLink 1120 - Disclosure - Loss per Share link:presentationLink link:calculationLink link:definitionLink 1130 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 1140 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 1150 - Disclosure - Employee Benefit Plan link:presentationLink link:calculationLink link:definitionLink 1160 - Disclosure - Related-Party Transactions link:presentationLink link:calculationLink link:definitionLink 1170 - Disclosure - Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 1180 - Disclosure - Quarterly Financial Information (unaudited) link:presentationLink link:calculationLink link:definitionLink 1190 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 2020 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 3020 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 3030 - Disclosure - Fair Value of Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 3040 - Disclosure - Inventories (Tables) link:presentationLink link:calculationLink link:definitionLink 3050 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 3060 - Disclosure - Intangible Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 3070 - Disclosure - Accrued Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 3080 - Disclosure - Convertible Senior Secured Notes (Tables) link:presentationLink link:calculationLink link:definitionLink 3110 - Disclosure - Share-Based Payments (Tables) link:presentationLink link:calculationLink link:definitionLink 3120 - Disclosure - Loss per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 3130 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 3140 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 3180 - Disclosure - Quarterly Financial Information (unaudited) (Tables) link:presentationLink link:calculationLink link:definitionLink 4010 - Disclosure - Organization and Nature of Operations (Details) link:presentationLink link:calculationLink link:definitionLink 4020 - Disclosure - Summary of Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 4021 - Disclosure - Summary of Significant Accounting Policies (Details 2) link:presentationLink link:calculationLink link:definitionLink 4022 - Disclosure - Summary of Significant Accounting Policies (Details 3) link:presentationLink link:calculationLink link:definitionLink 4023 - Disclosure - Summary of Significant Accounting Policies (Details 4) link:presentationLink link:calculationLink link:definitionLink 4024 - Disclosure - Summary of Significant Accounting Policies (Details 5) link:presentationLink link:calculationLink link:definitionLink 4030 - Disclosure - Fair Value of Financial Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 4031 - Disclosure - Fair Value of Financial Instruments (Details 2) link:presentationLink link:calculationLink link:definitionLink 4032 - Disclosure - Fair Value of Financial Instruments (Details 3) link:presentationLink link:calculationLink link:definitionLink 4033 - Disclosure - Fair Value of Financial Instruments (Details 4) link:presentationLink link:calculationLink link:definitionLink 4034 - Disclosure - Fair Value of Financial Instruments (Details 4) (Calc 2) link:presentationLink link:calculationLink link:definitionLink 4040 - Disclosure - Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 4050 - Disclosure - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 4060 - Disclosure - Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 4070 - Disclosure - Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 4080 - Disclosure - Convertible Senior Secured Notes (Details) link:presentationLink link:calculationLink link:definitionLink 4081 - Disclosure - Convertible Senior Secured Notes (Details 2) link:presentationLink link:calculationLink link:definitionLink 4090 - Disclosure - Sale of TCD Royalty Sub Reported as Discontinued Operations (Details) link:presentationLink link:calculationLink link:definitionLink 4100 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 4110 - Disclosure - Share-Based Payments (Details) link:presentationLink link:calculationLink link:definitionLink 4111 - Disclosure - Share-Based Payments (Details 2) link:presentationLink link:calculationLink link:definitionLink 4112 - Disclosure - Share-Based Payments (Details 3) link:presentationLink link:calculationLink link:definitionLink 4120 - Disclosure - Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 4130 - Disclosure - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 4131 - Disclosure - Income Taxes (Details) (Calc 2) link:presentationLink link:calculationLink link:definitionLink 4140 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 4150 - Disclosure - Employee Benefit Plan (Details) link:presentationLink link:calculationLink link:definitionLink 4160 - Disclosure - Related-Party Transactions (Details) link:presentationLink link:calculationLink link:definitionLink 4170 - Disclosure - Collaboration Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 4180 - Disclosure - Quarterly Financial Information (unaudited) (Details) link:presentationLink link:calculationLink link:definitionLink 4190 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink 8000 - Disclosure - Basis of Presentation link:presentationLink link:calculationLink link:definitionLink 8010 - Disclosure - Management's Plans as to Continuing as a Going Concern (Details 2) link:presentationLink link:calculationLink link:definitionLink 8020 - Disclosure - Changes in Accumulated Other Comprehensive Income link:presentationLink link:calculationLink link:definitionLink 8030 - Disclosure - Summary of Significant Accounting Policies (Details 6) link:presentationLink link:calculationLink link:definitionLink 8040 - Disclosure - Changes in Accumulated Other Comprehensive Income (Tables) link:calculationLink link:definitionLink link:presentationLink 8050 - Disclosure - Changes in Accumulated Other Comprehensive Income (Details) link:presentationLink link:calculationLink link:definitionLink 8060 - Disclosure - Share-Based Payments (Details 4) link:presentationLink link:calculationLink link:definitionLink 8070 - Disclosure - Summary of Significant Accounting Policies (Details 8) link:presentationLink link:calculationLink link:definitionLink 8080 - Disclosure - Convertible Senior Secured Notes (Details 3) link:presentationLink link:calculationLink link:definitionLink 8100 - Disclosure - Management's Plans as to Continuing as a Going Concern link:presentationLink link:calculationLink link:definitionLink 8110 - Disclosure - Management's Plans as to Continuing as a Going Concern (Details) link:presentationLink link:calculationLink link:definitionLink